Asymmetry in the structure of the ABC transporter-binding protein complex BtuCD-BtuF. Distinct gate conformations of the ABC transporter BtuCD revealed by electron spin resonance spectroscopy and chemical cross-linking. Structure of AMP-PNP–bound BtuCD and mechanism of ATP-powered vitamin B12 transport by BtuCD–F. Korkhov, V.M., Mireku, S.A., Veprintsev, D.B. Structure of AMP-PNP-bound vitamin B12 transporter BtuCD–F. ABC transporter-mediated uptake of iron, siderophores, heme and vitamin B12. Recent insights into iron import by bacteria. Carbon catabolite repression of the maltose transporter revealed by X-ray crystallography.
The allosteric regulatory mechanism of the Escherichia coli MetNI methionine ATP binding cassette (ABC) transporter. The ATP/substrate stoichiometry of the ATP-binding cassette (ABC) transporter OpuA. Crystal structure of a catalytic intermediate of the maltose transporter. Oldham, M.L., Khare, D., Quiocho, F.A., Davidson, A.L. Structure of an ABC transporter in complex with its binding protein. Structure of a bacterial ABC transporter involved in the import of an acidic polysaccharide alginate. Trapping the transition state of an ATP-binding cassette transporter: evidence for a concerted mechanism of maltose transport. Perspectives on the structure-function of ABC transporters: the Switch and Constant Contact models. Multidrug efflux pumps: the structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues. Structural insights into ABC transporter mechanism.
#Abc transporter full#
Uptake or extrusion: crystal structures of full ABC transporters suggest a common mechanism. Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain. coli methionine ABC transporter: structure and allosteric regulation. Kadaba, N.S., Kaiser, J.T., Johnson, E., Lee, A. Structural basis of trans-inhibition in a molybdate/tungstate ABC transporter. Gerber, S., Comellas-Bigler, M., Goetz, B.A. Prediction of drug-ABC-transporter interaction: recent advances and future challenges. Overview of experimental models of the blood-brain barrier in CNS drug discovery. A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. The controversial role of ABC transporters in clinical oncology. Tamaki, A., Ierano, C., Szakacs, G., Robey, R.W. Role of the bile salt export pump, BSEP, in acquired forms of cholestasis. Canalicular ABC transporters and liver disease. Molecular mechanisms for biliary phospholipid and drug efflux mediated by ABCB4 and bile salts. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Advances in the molecular detection of ABC transporters involved in multidrug resistance in cancer. The P-glycoprotein multidrug transporter. Multidrug resistance in cancer: role of ATP-dependent transporters. Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system. The transporter associated with antigen processing: a key player in adaptive immunity. The TAP translocation machinery in adaptive immunity and viral escape mechanisms. SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator. ABCC8 and ABCC9: ABC transporters that regulate K + channels. Evolution of ABC transporters by gene duplication and their role in human disease. Multifunctionality of plant ABC transporters: more than just detoxifiers. ABC transporters involved in drug resistance in human parasites. Molecular basis of multidrug transport by ABC transporters. Towards understanding promiscuity in multidrug efflux pumps. Wong, K., Ma, J., Rothnie, A., Biggin, P.C. Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli. ABC transporters involved in export of cell surface glycoconjugates. Lipid A modification systems in gram-negative bacteria. Raetz, C.R.H., Reynolds, C.M., Trent, M.S. The substrate-binding protein in bacterial ABC transporters: dissecting roles in the evolution of substrate specificity.
A structural classification of substrate-binding proteins. Structure, function, and evolution of bacterial ATP-binding cassette systems.
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